Theories Of Scaling Down/Scale-Up Tangential Flow Filters

Permeation flux thiab permeability yog ob qhov tseem ceeb hauv kev pom cov membrane. Permeation flux yog qhov ntim ntawm cov kua uas tuaj yeem dhau los ntawm ib chav tsev lub sijhawm thiab ib cheeb tsam ntawm daim nyias nyias. Permeability yog qhov sib piv ntawm cov concentration ntawm cov khoom lag luam hauv lub permeate rau nws cov concentration hauv cov tshuaj rov qab. Thaum sib piv tangential flow filters ntawm ntau qhov sib txawv, nws yog ib qho tsim nyog los tswj cov kev hloov pauv kom txo qis kev cuam tshuam: xaiv cov khoom siv sib xws, qhov pore loj, thiab cov chaw tsim khoom; siv cov kev daws teeb meem pub nrog zoo tib yam muaj pes tsawg leeg thiab concentration; thiab ua cov kev sim nyob rau hauv ib qho chaw txias txias. Thaum cov xwm txheej no tau ua tiav, nws tseem yuav tsum tau tswj cov kev sim ua raws li peb lub hauv paus ntsiab lus (cov khoom noj khoom haus tib lub ntim ntawm ib chav tsev membrane, tib lub zog shear, thiab tib lub hauv paus dej flux) kom ntseeg tau tias cov dej permeation thiab permeability ntawm cov ntxaij lim dej sib txawv yog kwv yees li ntawm txhua lub sijhawm.

 

Lub hauv paus ntsiab lus 1: Cov khoom noj khoom haus tib lub lim dej sib haum mus rau ib chav tsev membrane.

Permeation flux, permeability, thiab daim nyias nyias muaj feem cuam tshuam. Dhau li ntawm kev ua kom cov khoom siv membrane tib yam thiab qhov pore loj, kom ua tiav tib lub permeation flux thiab permeability, lub membrane deg tej yam kev mob (filter ncuav mog qab zib thiab concentration polarization) ntawm cov ntxaij lim dej loj thiab me yuav tsum zoo ib yam nyob rau txhua lub sij hawm. Txhawm rau ua kom lub ncuav mog qab zib lim thiab concentration polarization zoo ib yam ntawm daim nyias nyias, qhov ntim ntawm cov kua dej tib yam (cov tshuaj, cov concentration) lim hauv ib cheeb tsam yuav tsum zoo ib yam rau cov lim loj thiab me. Yog li ntawd, qhov sib piv ntawm cov kua ntim ntawm cov lim loj thiab me me yuav tsum sib npaug rau qhov sib npaug ntawm lawv qhov chaw ntawm daim nyias nyias, piv txwv li, qhov ntim ntawm cov kua dej sib txuas rau tib chav tsev membrane cheeb tsam.

 

Txoj Cai 2: Lub zog shear rau ntawm daim nyias nyias yog tib yam.

Hauv kev lag luam biopharmaceutical, cov kev daws teeb meem pub noj uas yuav tsum tau lim dej feem ntau yog siv tshuaj lom neeg. Lub zog shear rau ntawm daim nyias nyias tsis tsuas yog cuam tshuam rau kev tsim cov ncuav mog qab zib lim thiab concentration polarization, tab sis kuj yog bioactivity ntawm cov khoom lom. Yog li ntawd, nws yog ib qho tsim nyog los xyuas kom meej tias lub zog shear rau ntawm daim nyias nyias ntawm ob qhov loj thiab me tangential ntws lim yog tib yam thaum lub sijhawm ua haujlwm.

 

Txoj Cai3 : Tib qhov pib flux

Nyob rau hauv tib yam kev mob ntawm pub kua, daim nyias nyias ntawm cov khoom thiab cov kev khiav hauj lwm tej yam kev mob, yog hais tias tus thawj flux yog zoo tib yam thiab cov ntaub so ntswg hloov pauv zoo sib xws, cov flux tom ntej feem ntau yuav zoo sib xws. Yog li ntawd, nws yog ib qho tsim nyog los xyuas kom meej tias qhov pib flux zoo ib yam kom cov flux sib haum rau txhua lub sij hawm ntawm cov lim loj thiab me me zoo sib xws.

Txawm hais tias cov khoom siv membrane, qhov pore loj, thiab cov chaw tsim khoom ntawm cov ntxaij lim dej loj thiab cov me me zoo ib yam, lawv cov kev pom tag nrho sib txawv vim qhov sib txawv ntawm cov txheej txheem membrane packing. Thaum qhov pom kev tawm tsam ntawm cov lim loj thiab me me sib txawv, qhov sib txawv ntawm qhov sib txawv ntawm qhov siab ntawm qhov siab (TMP) yuav tsum tau ua kom tiav tib lub permeate flux. Feem ntau, qhov transmembrane siab (TMP) yog qhov sib txawv ntawm qhov nruab nrab qhov hluav taws xob qhov hluav taws xob thiab qhov hluav taws xob siab thiab qhov permeate siab. Txij li thaum lub permeate nyob rau hauv ob qho tib si loj thiab me lim yog txuas nrog atmospheric siab, lub permeate siab nyob rau hauv ob leeg yog 0 Pa. (gauge siab). Yog li ntawd, lub transmembrane siab nyob rau hauv qhov kev sim yog qhov nruab nrab ntawm lub inlet siab thiab lub qhov hluav taws xob siab.

Thaum tag nrho peb lub hauv paus ntsiab lus saum toj no txaus siab, thiab nrog tib yam kev mob pib, theoretically, permeation flux nyob rau tib lub sijhawm tom qab kev pom pib rau ob lub lim loj thiab me yuav zoo ib yam. Thaum lub permeation flux ntawm txhua lub sijhawm yog tib yam, nws tuaj yeem txiav txim siab tias lub sijhawm pom tag nrho rau ob hom lim dej sib npaug. Saib daim duab hauv qab no.

 

 

Schematic daim duab ntawm kev sib cuam tshuam sab hauv ntawm cov physicochemical thiab kev ua haujlwm tsis zoo

Cov ntaub ntawv: Guo Shuyin. Tsim thiab txheeb xyuas cov lim dej me me tangential thiab txoj kev xav ntawm tangential flow filter scaling down/up [D]. East China University of Science thiab Technology, 2016.